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In studies with healthful volunteers of one doses as much as 800 mg, adverse reactions ended up just like those witnessed at lower doses but incidence costs and severities were being enhanced.
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abnormal vision, for instance adjustments in shade vision (for example using a blue color tinge) and blurred vision
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Viagra had no effect on saquinavir pharmacokinetics. A more robust CYP3A4 inhibitor which include ketoconazole or itraconazole could possibly be envisioned to possess greater impact than that noticed with saquinavir. Inhabitants pharmacokinetic data from individuals in medical trials also indicated a discount in sildenafil clearance when it absolutely was co-administered with CYP3A4 inhibitors (for instance ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
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